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Oral precancerous lesions, such as leukoplakia and erythroplakia, represent a significant health concern due to their potential for malignant transformation. This research explores the efficacy of Photodynamic Therapy (PDT) as a non-invasive treatment modality in the management of these lesions. A diverse sample of 100 participants was subjected to standardized PDT protocols, with data collected to assess lesion size reduction, patient-reported outcomes, and recurrence rates during a 2-year follow-up period. The findings reveal a highly statistically significant reduction in lesion size following PDT (average reduction of 70.6%), highlighting its potential to target and eliminate these lesions effectively. Moreover, patients reported significant pain relief and a marked improvement in their quality of life, emphasizing the holistic benefits of PDT. Notably, the low recurrence rate of 8% observed suggests that PDT may inhibit the progression of precancerous lesions to malignancy. These results position PDT as a valuable and patient-centered treatment option for oral precancerous lesions. The observed immediate increase in inflammation levels post-PDT underscores the need for future research to understand the modulation of the tumor microenvironment. In conclusion, this study contributes to the growing body of evidence supporting PDT as a promising approach in the management of oral precancerous lesions, offering both physical and patient-centered benefits while reducing the risk of recurrence.

Keywords: Therapy, Oral, Management, PDT.