The purpose of this paper is to study the relationship between corporate social responsibility and the social entrepreneurship of 104 Tunisian companies. A survey of 104 small and medium companies and NGOs revealed the existence of a direct and positive relationship between the four dimensions of corporate social responsibility, namely economic responsibility, legal responsibility, philanthropic responsibility, and ethical responsibility, and the social entrepreneurship which consists of five axes; social vision, financial return, sustainability, innovativeness, and social network. From this study, we can emphasize the idea that, more the Tunisian companies integrate social, environmental, and economic concerns into their values, their culture, their decisions, their strategy, and their operations in a transparent and accountable manner, more they develop practices to meet market shortcomings with a clear social vision of transformative innovations, a significant financial income, a continued sustainability continues, and a well woven social network. This article provides recommendations for companies of how their responsible behavior positively influences their entrepreneurial orientation in social way. Key Words: Innovativeness, Social Entrepreneurship, Corporate Social Responsibility, Social Vision, Social Networking.