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Modified titanium surfaces are widely used in dental and orthopedic implants because they can improve osseointegration and promote the cell function. Biomimetic clinoptilolite natural zeolite coat was prepared successfully on the surface of the nano-porous titanium by anodization process. Novel natural zeolite coatis proposed to enhance biocompatibility of titanium. In vitro, results show that, rabbit bone marrow–derived mesenchymal stem cells (rBMSCs) has higher viability, cell proliferation, cell attachment, and alkaline phosphates (ALP) over 21 days period on the zeolite microstructure surface compared with uncoated titanium surface, indicating that the zeolite are highly biocompatible and non-cytotoxic coat. Results show that high corrosion resistance porous titania coated with zeolite has the superior ability of bone-like nodule formation, which can be used as a cancellous bone substitute. In conclusion, TiO2 and ZNT are very promising and are better understanding of cell/biomaterial interactions. Their mechanisms can help in the development of more effective orthopedic and dental implants. Key Words: Natural zeolite, Nano-porous Titania, Stem Cells, Alkaline Phosphates.